منابع مشابه
Bacterial adhesion: modulation by antibiotics which perturb protein synthesis.
It has been known for a long time that antibiotics are capable of altering bacterial surfaces, resulting in morphological changes that can be detected by electron microscopy (2); however, more subtle alterations at the molecular level may be undetectable at the ultrastructural level. Certain antibiotics disturb the metabolism and processing of bacterial surface components (59, 71), whereas othe...
متن کاملInhibition of bacterial adhesion by subinhibitory concentrations of antibiotics.
BACKGROUND Urinary Tract Infections (UTIs) due to Escherichia coli is one of the most common diseases encountered in clinical practice. Most common recognised pathogenic factor in E.coli is adhesion. There is accumulating evidence that through subinhibitory concentrations (sub-MICs) of many antibiotics do not kill bacteria, they are able to interfere with some important aspects of bacterial cel...
متن کاملHost and bacterial adhesion.
Bacterial adhesion is an important step in tissue colonization and depends extensively on the surface properties of a bacterial cell. For many microorganisms the prerequisite for host body occupancy is a break in tissue continuity. The next step is ongoing tissue destruction by products of bacterial metabolism: microbial enzymes and toxins. This happens, for example, in the initial phase of per...
متن کاملBacterial adhesion: modulation by antibiotics with primary targets other than protein synthesis.
By inhibiting dihydropteroate synthetase and dihydrofolate reductase, sulfonamides and trimethoprim inhibit the synthesis of folate coenzymes and thereby affect the central pathway of the metabolism of C1 compounds (25). The sub-MIC of trimethoprim was shown to reduce the fimbriation, hemagglutination, and epithelial cell adhesion of several Escherichia coli strains (49, 55, 61) through the inh...
متن کاملeffects of antibiotics on adhesion and invasion of proteus mirabilis
the ability of subminimum inhibitory concentrations (sub-mics) of antibiotics to affect the virulence factors of bacteria may be an important criterion in selecting an antibiotic for therapy. proteus mirabilis is one of the most frequently seen pathogens in urinary tract infections. the aim of this study was to analyze the effects of some antibiotics on two important virulence factors of p. mir...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1986
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/18.5.553